Focused Ultrasound Neuromodulation

info

To register, please visit the online store.

Registration costs £120 and includes lunch, coffee/tea, social drinks, and college dinner.

Spaces at the symposium are limited (only 37 left), so please register sooner rather than later.

Lunch and coffee/tea will be offered at Oriel college. On Monday night, we will host social drinks and college dinner for all attendees. All included in the registration. Please see below for a tentative programme.

  Monday Tuesday
9.00 registration coffee
9.30 talk: Yoo talk: Aubry
10.05 talk: Pauly talk: ter Haar
10.40 coffee, posters coffee, posters
11.10 talk: Treeby talk: Martin
11.45 talk: Contera talk: Legon
12.20 talk: Verhagen talk: Folloni
12.55 lunch, posters lunch, posters
14.15 talk: Shapiro talk: Jerusalem
14.50 talk: Caskey talk: Gallea
15.25 talk: Cleveland talk: Heimburg
16.00 coffee, posters coffee, posters
16.30 talk: Pouget talk: Monti
17.05 talk Konofagou talk: Hymynen
17.40 drinks closing
19.00 college dinner  

The symposium will be held on the 23rd and 24th of September 2019 at the Harris Lecture Theatre in Oriel College. Oriel is conveniently situated on Oxford’s High Street. Its central location means that many University departments and facilities (including the Bodleian Library) are within easy reach; the shops, restaurants, and hotels of Oxford are also close by.

We would like to invite all attendees to present their work during the poster sessions. Posters are in A0 portrait orientation and will be avaialbe for the whole duration of the symposium. Coffee, tea, and lunch are served in the poster room and we host a dedicated poster session with free drinks on Monday afternoon.

Abstract submission for posters is now open until 2nd Sept 2019. Please email them to funoxford2019@gmail.com. The content of the abstract should fit on one A4 page. We prefer short abstracts with figures.

The scientific committee will review the submissions, select a set of posters for presentation, and will send a notification of acceptance. For any question with regards to submissions, please contact funoxford2019@gmail.com.

We will bring together researchers developing and using ultrasound stimulation as a tool for cognitive neuroscience and clinical applications. This symposium will have a strongly integrative and translational approach from mechanisms, to neural circuits, to applications, from engineering, to neuroscience, to the clinic.

Key dates
September 2, 2019 deadline for poster submission
September 9, 2019 notification of poster acceptance
September 13, 2019 deadline for registration
September 23-24, 2019 symposium

 

Oriel College, Oxford

Yes, it is sometimes sunny in Oxford. If you are lucky it may also be "warm".

travel

The closest airport to Oxford. An hour-ish ride on a bus will take you to Oxford city center: https://airline.oxfordbus.co.uk/heathrow/

Second best airport to land at, you will need to jump on a bus for another 2h30 to reach Oxford: https://airline.oxfordbus.co.uk/gatwick/

For the train afficionados or London lovers, you could also take the train to Victoria train station https://www.gatwickexpress.com/)

 

Stansted

I feel sorry for you! The journey to oxford will be either a long ride on a bus (https://www.nationalexpress.com/en/destinations/oxford/stansted-to-oxford), or you will have to make a detour via London (https://www.stanstedexpress.com; there are also buses). It could be an opportunity to visit some of the many attractions of the english capital.

Luton

Not much better than Stansted I'm afraid. While it is only a 1 hour trip to Oxford if you can rent a car, the bus takes about 2.5 hours and leaves every two hours (https://www.nationalexpress.com/en/destinations/oxford/luton-to-oxford). 

Birmingham

Not too horrible, actually. Not many transatlantic flights either, but if you do catch one, you are just an hour away from Oxford by train, leaving straight from the airport (https://www.thetrainline.com/train-times/birmingham-international-to-oxford). There is also a cheaper and slower bus service (https://www.nationalexpress.com/en/airports/birmingham).

If you have arrived at St Pancras or Liverpool street station, your journey is not yet over!

Train

The average journey time between Oxford and London is 1 hour 14 minutes . The fastest journey time is 52 minutes. On an average weekday, there are 77 trains per day travelling from Oxford to London. Trains to Oxford depart from Paddington or Marylebone train stations.

https://www.thetrainline.com/train-times/oxford-to-london

Bus 

Two coach services up to every 12 minutes 24 hours a day, delivering a very reliable service for commuters: Oxford Tube and X90. These services have slightly different stops in London, but stop at the same useful places in Oxford (including very near to Oriel College). These are your cheapest options. Journey duration will be approximately 2 hours (depending on traffic).

https://www.oxfordtube.com

https://x90.oxfordbus.co.uk

accommodation

In Oxford, many colleges put their fellow and student accomodation up for rent outside of term time. These can be more affordable than hotels or B&Bs and can give you a taste of college life. Have a look at these services to find a room.

 

University Rooms
https://www.universityrooms.com/en-GB/city/oxford

 

Conference Oxford
http://conference-oxford.com/bb-self-catering

There are quite a few options for B&Bs in Oxford, all listed at the usual places: airbnb.co.uk, booking.com, etc. Here is a selection of hotels and B&Bs, in no specific order.

Oxford University Club
11 Mansfield Rd, Oxford, OX1 3SZ
http://www.club.ox.ac.uk
Rates from £104 per night
Cotswold Lodge Hotel
66a Banbury Road, Oxford, OX2 6JP
https://www.cotswoldlodgehotel.co.uk
enquiries@cotswoldlodgehotel.co.uk
tel: +44 1865 512 121
George Street Hotel
15-19 George Street, Oxford, OX1 2AB
https://www.gshoxford.co.uk
reservations@gshoxford.co.uk
tel: +44 (0)1865 957 800
Linton Lodge Hotel
11-13 Linton Road, Oxford, OX2 6UJ
http://www.bw-lintonlodgehotel.co.uk
sales@lintonlodge.com
tel: +44 (0)1865 553 461
Jury’s Inn Hotel
Godstow Rd, Oxford, OX2 8AL
https://www.jurysinns.com
tel: +44 (0)870 4100 800
Parklands B&B
100 Banbury Rd, Oxford, OX2 6JU
https://www.parklandsoxford.co.uk
stay@parklandsoxford.co.uk
tel: +44 (0)1865 554 374
St Margaret’s Hotel
41 St Margaret’s Rd, Oxford, OX2 6LD
http://www.thestmargaretshotel.co.uk
tel: +44 (0)1865 433 864
The Oxford Townhouse
90 Abingdon Road, Oxford, OX1 4PX
https://www.theoxfordtownhouse.co.uk
stay@theoxfordtownhouse.co.uk
tel: +44 (0)1865 511 122
Lonsdale Guest House
312 Banbury Road, Oxford, OX2 7ED
https://www.lonsdaleguesthouse.com
info@lonsdaleguesthouse.com
tel:+44 (0) 795 6410 489
Royal Oxford Hotel
Park End Street, Oxford, OX1 1HR
https://www.royaloxfordhotel.co.uk
info@royaloxfordhotel.co.uk
tel: +44 (0)1865 248 432
The Galaxie Hotel
180 Banbury Rd, Oxford, OX2 7BT
http://www.galaxie-booking.com
hotel@galaxie.co.uk
tel: +44 (0) 1865 515688
Holiday Inn Oxford
Peartree Roundabout, Woodstock Rd
Oxford, OX2 8JD
https://www.ihg.com/holidayinn/hotels/gb/en/oxford
tel: +44 (0) 3714 234 876

 

speakers

Central and peripheral modulation in mice and humans using focused ultrasound

Ultrasound has been consistently reported for neuronal stimulation for several decades in both animals and humans including eliciting brain activity detected by functional MRI and electroencephalography. In addition, this knowledge can be used to understand the differences between normal and pathological brains to treat patients. In the peripheral nervous system, the leading technique to treat peripheral neurological disorders is implantation of electrodes along the peripheral nerve and stimulating the nerve with electrical current. A noninvasive alternative that could treat neuropathic pain and suppress nerve activity constitutes thus an important challenge in interventional neurology.Our group has been studying the noninvasive stimulation or inhibition of both the central and peripheral nervous system in live animals. In the brain, we have shown that focused ultrasound is capable of noninvasively stimulating paw movement as well as sensory responses such as pupil dilation and eye movement when different brain regions are targeted, showing for the first time that ultrasound can trigger both motor and sensory brain responses. In the periphery, when the ultrasound beam is focused on the sciatic nerve in a live, anesthetized animal, the thigh muscle becomes activated and muscle twitches can be induced at low ultrasonic intensities while the same twitches can be inhibited at higher intensities due to associated temperature rise that inhibits nerve firing. In humans, a peripheral sensory response has also been elicited. Cellular and fiber responses in excised tissue have confirmed the live animal responses. An overview of the aforementioned findings together with the most recent results will be presented.

Elisa E. Konofagou, PhD

Elisa Konofagou

Elisa E. Konofagou is the Robert and Margaret Hariri Professor of Biomedical Engineering and Professor Radiology as well as Director of the Ultrasound and Elasticity Imaging Laboratory at Columbia University in New York City. Her main interests are in the development of novel elasticity imaging techniques and therapeutic ultrasound methods and more notably focused ultrasound in the brain for drug delivery and stimulation, myocardial elastography, electromechanical and pulse wave imaging, harmonic motion imaging with several clinical collaborations in the Columbia Presbyterian Medical Center and elsewhere. Elisa is an Elected Fellow of the American Institute of Biological and Medical Engineering, a member of the IEEE in Engineering in Medicine and Biology, IEEE in Ultrasonics, Ferroelectrics and Frequency Control Society, the Acoustical Society of America and the American Institute of Ultrasound in Medicine. She has co-authored over 200 published articles in the aforementioned fields. Prof. Konofagou is also a technical committee member of the Acoustical Society of America, the International Society of Therapeutic Ultrasound, the IEEE Engineering in Medicine and Biology conference (EMBC), the IEEE International Ultrasonics Symposium and the American Association of Physicists in Medicine (AAPM). Elisa serves as Associate Editor in the journals of IEEE Transactions in Ultrasonics, Ferroelectrics and Frequency Control, Ultrasonic Imaging and Medical Physics, and is recipient of awards such as the CAREER award by the National Science Foundation (NSF) and the Nagy award by the National Institutes of Health (NIH) as well as others by the American Heart Association, the Acoustical Society of America, the American Institute of Ultrasound in Medicine, the Wallace H. Coulter foundation, the Bodossaki foundation, the Society of Photo-optical Instrumentation Engineers (SPIE) and the Radiological Society of North America (RSNA).

Biomolecular Engineering for Focused Ultrasound Control of Cellular Function

The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular functionin vivo. Technologies such as optogenetics serve this purpose in small, translucent specimens, but are limited by the poor penetration of light into deeper tissues. In contrast, non-invasive techniques such as ultrasound – while based on energy forms that penetrate tissue effectively – are not as effectively coupled to cellular function. Our work attempts to bridge this gap by engineering biomolecules with the appropriate physical properties to interact with sound waves, and to enhance the transport of engineered biomolecules into tissues such as the brain. In this talk, I will focus on our work to understand the biophysical, molecular, and circuit mechanisms by which ultrasound can directly modulate neural activity, and methods of combining ultrasound with viral vectors and engineered receptors to enable convenient, scalable and cell-type specific control of neural circuits. In addition, I will describe two classes of biomolecular acoustic actuators that may in the future be applied to the brain. One is based on temperature-dependent transcriptional repressors, which provide switch-like control of gene expression in response to small changes in temperature. Another is based on genetically encodable air-filled protein nanostructures known as gas vesicles, which can be converted to free bubbles using low frequency ultrasound, enabling them to serve as molecularly targeted or genetically encoded seeds for inertial cavitation. 

Mikhail G. Shapiro, PhD

shapiro

Mikhail Shapiro is a Professor of Chemical Engineering and an Investigator of the Heritage Medical Research Institute at Caltech. The Shapiro laboratory develops biomolecular technologies allowing cells to be imaged and controlled inside the body using sound waves and magnetic fields to enable the study of biological function in vivo and the development of cell-based diagnostic and therapeutic agents. Mikhail received his PhD in Biological Engineering from MIT and his BSc in Neuroscience from Brown, and conducted post-doctoral research at the University of Chicago and the University of California, Berkeley, where he was a Miller Fellow. Mikhail’s awards include the Packard Fellowship, the Pew Scholarship, the Camille Dreyfus Teacher-Scholar Award and the Roger Tsien Award for Excellence in Chemical Biology. More information about the Shapiro Lab can be found online at shapirolab.caltech.edu

Single element low intensity transcranial focused ultrasound for human neuromodulation applications

Low intensity transcranial focused ultrasound (LIFU) is a promising non-surgical low-energy technique for transient neuromodulation with high spatial resolution and adjustable focus suitable for targeting cortical and sub-cortical human brain regions. Here, we will discuss current state of the art as well as progress and challenges for developing LIFU for human clinical applications. 

Wynn Legon, PhD

Wynn Legon

Assistant Professor, Department of Neurosurgery University of Virginia

Dr. Legon studies the use of ultrasound for cortical and sub-cortical neuromodulation in humans using EEG, fMRI, computer modelling and empirical testing in an effort to advance ultrasound for potential neurological diagnostic and therapeutic applications in health and disease.

The soliton theory for nerve excitation and the time-scales of excitation

The soliton theory provides an alternative explanation for the nervous impulse based on cooperative melting transitions in the biomembrane.  It relies on reversible electromechanical processes and the thermodynamics of membranes. During the nervous impulse, the membrane is shifted through its transition, with associated changes in heat capacity, compressibility and inherent time-scales. The latent heat of the transition explains the sign and the magnitude of the experimentally observed reversible heat production of the action potential and the observed changes in nerve dimension (shortening and increase in membrane thickness). The dimensional changes give rise to the possibility to excite the nerve mechanically or thermally.

In the transition, one finds fluctuations in the membrane permeability corresponding to spontaneous pore formation, which in a patch clamp experiment are indistinguishable from the quantized current events usually attributed to protein channels.  They show most features of protein channels including temperature- and mechano-sensitivity, and voltage-gating. Their characteristic open time scales can be understood in the context of the fluctuation theorems applied to a membrane.

Membrane fluctuations therefore provide an estimate for the most suitable time-scale of membrane excitation. After a perturbation, relaxation processes in artificial membranes may display relaxation time scales up to several seconds. In biomembranes close to transitions, the expected relaxation time scales are expected to be in the millisecond regime. This is also the time scale of the open-lifetimes of membrane pores - and as it happens, the typical lifetime of protein channels. Therefore, we argue that this is also the time-scale of the most effective nerve membrane excitation.

Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound and its effects on learning and decision-making

Focused Transcranial Ultrasound Stimulation enables us to non-invasively and transiently modulate activity in subcortical and deep cortical brain structures, without the need of any surgical procedure. I am particularly interested in using low-intensity ultrasound stimulation to investigate the neural and behavioural effects resulting from a transient interference of neural communication between different brain regions within a circuitry. The capacity of transcranial focused ultrasound stimulation to alter activity in regions located deep below cortex will allow us to better understand the contribution of these structures to normal and pathological cognition.

Davide Folloni

Davide Folloni

Davide Folloni is a PhD student in Neuroscience interested in understanding the functional dynamics of the neural circuits supporting learning and decision making. Its research uses a multi-modal approach to describe the anatomy, organization and neural activity of different brain networks. Specifically, he uses transcranial focused ultrasound stimulation in combination with functional Magnetic Resonance Imaging to manipulate the activity of subcortical and cortical brain structures and causally infer their role in normal and abnormal cognitive computations underlying decision-making.

organizers

sallet

Jerome investigates the neurobiological basis of adaptive behaviors in human and non-human primates. He completed a PhD in cognitive neuroscience from Lyon 1, before joining the University of Oxford. He is currently a PI at the Department of Experimental Psychology in Oxford.

stagg

Charlotte J Stagg MRCP DPhil

Dr Charlotte (Charlie) Stagg is Professor of Human Neurophysiology and Head of the Physiological Neuroimaging Group at the Wellcome Centre for Integrative Neuroimaging (WIN), University of Oxford, UK. She has held a Sir Henry Dale Fellowship, funded by the Wellcome Trust and the Royal Society, since 2014.

Her inter-disciplinary group uses multi-modal neuroimaging and non-invasive brain stimulation approaches to understand the physiological processes underlying motor plasticity, both in the context of learning new motor skills and regaining function after a stroke. Her work has two overarching themes: to understand the mechanisms underpinning motor learning, and to develop non-invasive brain stimulation as a potential therapeutic intervention for rehabilitation.

https://www.ndcn.ox.ac.uk/research/physiological-neuroimaging-group

twitter: @cjstagg

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